Abstract
A polypseudorotaxane (PPR) nanoparticle was fabricated by the self-assembly of mPEG-protoporphyrin IX (PpIX) conjugate and α-CDs via the host-guest interaction. The nanoparticle loaded with anticancer drug doxorubicin (DOX) exerted synergistic photodynamic and chemotherapy. The nanoparticle was spherical with the mean size of 89nm, the low critical micelle concentration (CMC) of DOX-loaded nanoparticle was 9.3μg/mL and the drug loading content was 9.93%. The in vitro anticancer activity test revealed that the DOX-loaded nanoparticle exhibited promising reactive oxygen species (ROS) cytotoxicity and chemotherapeutic efficacy to cancer cells. The PPR nanoparticle is potentially promising for synergistic photodynamic and chemotherapy for cancers.
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