Abstract
Gastro-retentive drug delivery systems (GRDDS) have been developed with the aim of prolonging drug release. In this study, floating device systems (FDS) were developed and incorporated with a domperidone tablet (Motilium-M®). The FDSs were made of polyvinyl alcohol (PVA) using a fused deposition modelling (FDM) 3D-printer and crosslinked by thermal crosslinking process. The morphology, water insolubilization, water uptake, thermal analysis, FT-IR, floating time and drug release were investigated. The results showed that thermal crosslinking caused the structural change of PVA. Increasing the crosslinking time increased the crystallinity of the polymer resulted in the decreased water solubility, water uptake, and swelling property. An optimal crosslinking condition for the FDS was heating at 120 °C for 6 h. Floating time of the FDS decreased after the crosslinking process. However, the sustained drug release of domperidone from the FDSs were observed after the thermal crosslinking process.
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