Abstract
Esophageal stent implantation can relieve esophageal stenosis and obstructions in benign esophageal strictures, and magnesium alloy stents are a good candidate because of biodegradation and biological safety. However, biodegradable esophageal stents show a poor corrosion resistance and a quick loss of mechanical support in vivo. In this study, we chose the elastic and biodegradable mixed polymer of Poly(ε-caprolactone) (PCL) and poly(trimethylene carbonate) (PTMC) as the coated membrane on magnesium alloy stents for fabricating a fully biodegradable esophageal stent, which showed an ability to delay the degradation time and maintain mechanical performance in the long term. After 48 repeated compressions, the mechanical testing demonstrated that the PCL-PTMC-coated magnesium stents possess good flexibility and elasticity, and could provide enough support against lesion compression when used in vivo. According to the in vitro degradation evaluation, the PCL-PTMC membrane coated on magnesium was a good material combination for biodegradable stents. During the in vivo evaluation, the proliferation of the smooth muscle cells showed no signs of cell toxicity. Histological examination revealed the inflammation scores at four weeks in the magnesium-(PCL-PTMC) stent group were similar to those in the control group (p > 0.05). The α-smooth muscle actin layer in the media was thinner in the magnesium-(PCL-PTMC) stent group than in the control group (p < 0.05). Both the epithelial and smooth muscle cell layers were significantly thinner in the magnesium-(PCL-PTMC) stent group than in the control group. The stent insertion was feasible and provided reliable support for at least four weeks, without causing severe injury or collagen deposition. Thus, this stent provides a new stent for the treatment of benign esophageal stricture and a novel research path in the development of temporary stents in other cases of benign stricture.
Highlights
Diseases in the esophageal atrium often result in esophageal benign strictures
The stent consists of a cross-linked cross-linked magnesium alloy wire cylindrical mesh body
The design of the magnesium-(PCL-poly(trimethylene carbonate) (PTMC)) stent was able to carry out all requirements which included excellent tensile strength and good security with few complications
Summary
Diseases in the esophageal atrium often result in esophageal benign strictures This type of stricture can be caused by external pressure on the mucosal ring andstrictures. Diseases in the esophageal atrium often result in esophageal benign This type of benign of theby esophagus (BSE) can forand complications such as aspiration, stricturestricture can be caused external pressure on be theresponsible mucosal ring the mediastinal tissue. A benign weight loss, and malnutrition, reducing a patient’s quality of life [1] To combat these stricture of the esophagus (BSE) can be responsible for complications such as aspiration, weight side loss, effects, the use of an esophageal implantation been on patients and malnutrition, reducing stent a patient’s quality has of life [1].used. Clinical [2,3,4]
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