Abstract
This research was focused on the two-step regeneration of Antheraea mylitta (tasar) fibroin in the form of electrospun 3D self-assembled nanofibrous nonwoven mats using ionic liquid and formic acid/CaCl2. The self-assembled structure of tasar nanofibrous nonwoven mats was dependent on the silk fibroin concentration and spinning voltage. The secondary conformation of tasar fibroin protein before and after electrospinning was analyzed by Fourier transformation infrared spectroscopy. The morphology of the nanofibrous mat was studied by scanning electron microscope. The self-assembled 3D tasar nonwoven nanofibrous construct was a highly porous and spongy structure with high water absorption and water vapor transmission. Highly porous 3D self-assembled tasar nonwoven nanofibrous construct favored good growth and proliferation of L929 skin fibroblast cells. Based on these properties, 3D self-assembled tasar nonwoven nanofibrous construct is a promising material for skin tissue engineering and wound dressing applications.
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