Abstract
Calcium alginate hydrogel beads have been widely studied as a carrier matrix for the delivery of food and pharmaceutical compounds due to its non-toxicity, renewability, and the ease of forming hydrogel beads with divalent cations. However, alginate hydrogel beads are known to have low stiffness, i.e., Young’s modulus 0.96) and followed the Fickian mechanism (n 0.98) and followed the non-Fickian mechanism (0.43 0.98) and followed the Case-II transport mechanism (n > 0.85). It is worth noting that the ketoprofen release from UHC beads exhibited a time lag of 60 min. These findings show that the UHC calcium-alginate beads with high stiffness and extended dissolution profile can be prepared without the need for chemical modification, additional processing steps, or incorporation of additives. The UHC calcium-alginate beads open up the windows of opportunities for applications in sustained delivery of drugs and food ingredients.
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