Abstract
In this paper we present a new fabrication technique that only uses conventional techniques of microtechnology such as microlithography, thin-film deposition and directional ion beam etching to makevery narrow, wafer-scale length platinum (Pt) nanowires, named deposition and etching under angles (DEA). Then fabricated Pt nanowires electrodes were modified by using several chemicals to immobilize glucose oxidase (GOD) enzyme for application in glucose detection. A cyclic voltammetry (CV) technique was used to determine glucose concentrations. The detection results showed that GOD was immobilized on all of the tested surfaces and the highest glucose detection sensitivity of 60μM was obtained when the Pt nanowires were modified by PVA. Moreover, the sensors also showed very high current response when the Pt nanowires were modified with the cysteamine SAM.
Highlights
Nanoscale devices based on nanowires have been realized for applications in electronics, optics, gas, and especially biomedical sensing [1,2,3]
In this paper we present a new fabrication technique that only uses conventional techniques of microtechnology such as microlithography, thin-film deposition and directional ion beam etching, named deposition and etching under angles (DEA)
Cyclic voltammograms (CVs) were performed in glucose solution in PBS buffer and a variety of glucose concentrations in water to investigate the influence of electrolyte solution on the platinum electrode prior to the immobilization process
Summary
Nanoscale devices based on nanowires have been realized for applications in electronics, optics, gas, and especially biomedical sensing [1,2,3]. Surface properties are especially of concern because the interaction of any metal electrode with its environment mainly occurs at the surface, and because of the dependence of the response on the surface state of the electrode Many analytical applications, such as electron transfer reaction, preferential accumulation, or selective membrane permeation, can benefit from chemically modified electrodes [7,8,9]. Fabricated Pt nanowires electrodes were immobilized with GOD by using different techniques to investigate three generations of glucose sensor. The performance of the glucose biosensors, including the response time, enzymatic sensitivity and device durability, are reported
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