Abstract
In order to fabricate antibacterial nanofiber membranes for tissue engineering field, the oxidative damage of magnesium hydroxide nanoparticles (Mg(OH)2 NPs) against the model system of Escherichia coli (E. coli) was researched by measuring the oxidative stress response, oxidative stress products and glucose metabolism. The toxicity of Mg(OH)2 NPs to a normal biological system was evaluated in vivo through the acute oral toxicity, blood physiological and serum biochemical markers and acute skin irritation, indicating that the Mg(OH)2 NPs exhibited great biosafety. The Mg(OH)2 NPs with antibacterial property and biosafety were loaded on PCL/PVP nanofiber substrates through electrospinning technology to fabricate the Mg(OH)2/PCL/PVP nanofiber membranes. The results of characterization and antibacterial test showed that the Mg(OH)2/PCL/PVP nanofiber membranes with 8.0 wt% Mg(OH)2 NPs present excellent antibacterial rate of 100% against E. coli that the Mg(OH)2 NPs can be physically and evenly loaded on nanofiber substrates.
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