Abstract
Restricted self-recovery that pursues a bone injury and the need of inexpensive and painless clinical treatments for tissue regeneration require new pathways developments to fabricate biocompatible and biodegradable scaffolding materials. For these requirements, covalent crosslinked alginate and alginate/Mg-doped hydroxyapatite (MgHAp) hydrogels are fabricated by “click” chemistry to mimic highly porous structures with the dimensional hierarchy of bone tissue. Cells viability, proliferation and cytotoxicity are reported. These scaffolds show high pore volume with adequate size and interconnectivity for osseous tissue regeneration. An uniform dispersion of low content of bioactive MgHAp nanoparticles on the surface of pore walls allows a good preosteoblast cell attachment and proliferation.
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