Abstract
Folate-modified iron ferrite nanoparticles with high doxorubicin loading (FDMP) were developed for dual targeting of tumor cells. Large quantities of doxorubicin and folate ligand were chemically coupled to the synthesized dual-functional magnetic nanoparticles by using the multihand cross-linker poly-L-glutamic acid. FDMP exhibits high drug loading ability, narrow size distribution and pH sensitivity to drug release. The drug loading ratio and the magnetic response can be adjusted by controlling the reactant ratio. FDMP possesses high magnetic-guided ability and exhibits enhanced uptake by folate receptors expressing tumor cells and increased cancer cell cytotoxicity.
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