Fabrication and evaluation of slow-release lignin-based avermectin nano-delivery system with UV-shielding property

Dongmei Mo,Yuanfei Zhang,Yong Chen,Yanmin Huang,Jianguo Cui,Yang Jiang,Weiguo Li,Chunfang Gan,Xiangying Li

doi:10.1038/s41598-021-02664-7

Dongmei Mo, Yuanfei Zhang + Show 7 more

Open Access

https://doi.org/10.1038/s41598-021-02664-7

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Abstract

Nanopesticide is one of the best pesticide formulation technologies to overcome the disadvantages of traditional pesticides, which has received great attention from the international community. Using high-speed emulsification and ultrasonic dispersion technology, an avermectin nano-delivery system (Av-NDs) with a particle size of 80–150 nm was prepared through embedding the pesticide molecule utilizing the cross-linking reaction between sodium lignosulfonate and p-phenylenediamine diazonium salt. The formulation and composition of Av-NDs were optimized, the morphology of Av-NDs was analyzed by scanning electron microscope, transmission electron microscope and dynamic light scattering, and the structure of Av-NDs was characterized by UV, IR and 1H NMR. Anti-photolysis and controlled-release tests show that the stability of Av-NDs is 3–4 times of the original avermectin (Av) and possesses the pH-responsive controlled release property. Furthermore, the insecticidal activity of Av-NDs is better than that of avermectin suspension concentrate (Av-SC). The Av-NDs with anti-photolysis and controlled-release characteristics is suitable for large-scale industrial production and is capable to be utilized as effective insecticide in the field.

Highlights

Nanopesticide is one of the best pesticide formulation technologies to overcome the disadvantages of traditional pesticides, which has received great attention from the international community
Using p-phenylenediamine diazonium salt as a cross-linking agent, avermectin was embedded in the nanospheres through the cross-linking reaction between sodium lignosulfonate and p-phenylenediamine diazonium salt, and the nanoparticles formed were further dispersed and homogenized by ultrasonic dispersion method, and the avermectin nano-delivery system (Av-NDs) was obtained
The results showed that when s-butyl acetate was used as the solvent of avermectin, the nanoformulation obtained had smaller particle size and better storage stability

Summary

Introduction

Nanopesticide is one of the best pesticide formulation technologies to overcome the disadvantages of traditional pesticides, which has received great attention from the international community. Using high-speed emulsification and ultrasonic dispersion technology, an avermectin nano-delivery system (Av-NDs) with a particle size of 80–150 nm was prepared through embedding the pesticide molecule utilizing the cross-linking reaction between sodium lignosulfonate and p-phenylenediamine diazonium salt. Li Y. et al utilized the self-assembly of sodium lignosulfonate with CTAB (cetyltrimethylammonium bromide) to form a shell to wrap a vermectin[33]. Alkaline lignin into a structure containing a tetravalent ammonium salt group, and combined with SDBS (sodium dodecyl benzenesulfonate), an anionic surfactant, to form avermectin encapsulated matrix[34]. The above avermectin nanoformulations obtained by lignin showed better anti-photolysis and slow-release effects

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