Fabrication and Evaluation of Fast Disintegrating Oral Hybrid Films of Propranolol Hydrochloride by Using Pectin and Synthetic Polymers

Newton Amj,Rani Sm

doi:10.4172/2329-6631.1000157

Abstract

The main aim of this investigation is to develop fast disintegrating oral films of Propranolol hydrochloride by using Pectin and synthetic polymers. The Propranolol HCl oro-dispersible films were formulated by using HPMC E15LV, HPMC regular, pectin, Carbopol, and PVA, as film forming polymers. The selected polymers were natural and synthetic water soluble polymers. Generally solvent casting method was used in the manufacture of the mouth dissolving films. The formula which incorporates pectin HPMC E15 LV 4:2 and pectin: Carbopol 3:2 ratios and also other varying ratio were used in the formulation of Oro-dispersible films. The quantity and type of plasticizer affected the formulation of films; Propranolol HCl has bitter taste so taste masking agents were used. Citric acid was used as a salivary stimulating agent. The prepared films were subjected to the analysis of various evaluation tests such as weight variation, tensile strength, thickness, surface pH, and drug content. The significant parameters such as disintegration and dissolution profiles also studied in detail since the product was prepared for fast dissolving in the oral cavity.

Highlights

Hypertension is the chronic condition which is related to elevated arterial blood pressure
Pre formulation studies for propranolol HCl Thirteen formulations were prepared with different level addition of film forming polymers with different ratios of pectin, HPMC E15 LV, carbopol, poly vinyl alcohol and HPMC
The pH of the drug solution was tested by using pH meter 4% w/v solution of propranolol HCl was prepared by using methanol as a solvent and sonicated for 30 minutes

Summary

Introduction

Hypertension is the chronic condition which is related to elevated arterial blood pressure. The condition described as high blood pressure. In such conditions the heart has work harden than its regular pattern to maintain the circulation. Hypertension is of two type’s primary or secondary hypertension. In the total hypertensive population 90–95% cases falls in the class of "primary hypertension" for which underlying medical cause is understandable [1]. The secondary hypertension affects 5-10% of the cases that affect the kidneys, arteries, heart and endocrine system. If the blood pressure is not controlled alternative therapeutic approaches can be used to bring back the issue to normal [2]

Methods

Results

Conclusion