Fabrication and electrochemical properties of alizarin -aminophenylboronic acid ensembled with layered double hydroxide for glucose sensing selectivity

Abstract

The interaction of alizarin with aminophenylboronic acid (ARS-PBA) was used through a new strategy for electrochemical sensors of glucose. In the present work, ARS-PBA complex and the layered double hydroxide nanosheets (LDH nanosheets) were successfully assembled on indium tin oxide (ITO) electrodes via layer by layer technology method. The resulted electrode was characterized by UV–vis, X-ray diffraction (XRD), atomic force microscope (AFM) and scanning electron microscope (SEM) to achieve the morphological, structural and compositional information. Cyclic voltammetry and differential pulse voltammetry were conducted to investigate electrochemical properties of the modified electrode. Moreover, the modified electrode was used as a non-enzymatic sensor for glucose determination, exhibiting good electrochemical properties, fast response time and long-term stability. At the optimum conditions, the constructed electrode sensor shows a linear range of 0∼1.00 μmol/L and a low detection limit of 4.0 nmol/L (S/N = 3) for glucose. On the basis of affinity between glucose and ARS-PBA complex, the functionalized electrode showed a high selectivity toward glucose over other concomitant biomolecues (dopamine, uric acid and ascorbic acid). Therefore, a simple and effective electrochemical method was developed and offers a complementary tool for the detection of glucose.