Abstract
In this study, glassy carbon electrode(GCE) modified with zinc oxide nanoparticles (ZnO NPs) sensor was developed for paracetamol(PRM) detection. This antipyretic, anti-inflammatory drug usage is ample in medical field and over dose, continuing use for a long time affects kidney and liver because of accumulation of metabolite, hence paracetamol detection is significant. Cyclic voltametry (CV) and differential pulse voltametric (DPV) techniques were employed to analyse the behaviour of analyte on modified GCE in 0.2 M phosphate buffer solution (PBS) of physiological pH. ZnONP/GCE showed good linear response in the concentration range from 40.0 × 10−8 M to 24.0 × 10−6 M for quantitative determination of PRM with lower limit of detection of 3.6 nM. Developed technique was successfully applied to assay the content labelled in different PRM tablets. It also exhibited good selectivity, after series of common physiological intereferent's assessments. As a proof of concept, modified electrode was investigated in PRM spiked human urine samples.
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