Abstract
BackgroundTretinoin or all-trans retinoic acid is used in the treatment of acne vulgaris and photo-aging. This work aims to develop tretinoin-loaded nanofibers as a potential anti-acne patch and to investigate its physicochemical characteristics.MethodNanofibers were produced via electrospinning method and surface topography was evaluated by Field Emission Scanning Electron Microscopy (FESEM). The functional groups of polymer and the drug molecule and the possible interactions were studied by Fourier Transform Infrared Spectroscopy (FTIR). Drug release studies were carried out by total immersion method at 25 °C and 32 °C. Tretinoin stability was evaluated at room temperature and fridge for 45 days. The possibility of synergistic antibacterial activity of tretinoin and erythromycin combination was investigated on Staphylococcus aureus (ATCC® 25923™) and (ATCC® 29213™) by Kirby Bauer disc diffusion method.ResultsUniform fibers without drug crystals were fabricated via electrospinning. Drug-loaded nanofibers show inherent stability under various storage conditions. Electrospun nanofibers showed a prolonged release of tretinoin. The stability of formulations in FT was higher than RT. Disc diffusion tests did not show any synergism in the antibacterial activity of erythromycin when used in combination with tretinoin.ConclusionIt can be anticipated that the easy fabrication, low costs and dosing frequency of the construct reported here provide a platform that can be adapted for on-demand delivery of tretinoin.Graphical abstract
Highlights
Electrospinning is widely employed for the fabrication of high-quality nanofiber at low production cost
Electrospun nanofibers showed a prolonged release of tretinoin
The stability of formulations in fridge temperature (FT) was higher than room temperature (RT)
Summary
Electrospinning is widely employed for the fabrication of high-quality nanofiber at low production cost. Other application that can benefit from the favorable properties of nanofibers includes separation of contaminants from water and molecule filtration offered by the high efficiency and low Polycaprolactone (PCL) is a biodegradable and biocompatible synthetic hydrophobic polymer with a semicrystalline structure. It has been approved by the US Food and Drug Administration (FDA) and is being widely used in the design of various drug delivery systems [3, 4]. The topical application of this molecule enhances collagen (2020) 24:8 and hyaluronic acid production and is used as an antiaging regimen Oral administration of this drug is employed in the treatment of acute promyelocytic leukemia. This work aims to develop tretinoin-loaded nanofibers as a potential anti-acne patch and to investigate its physicochemical characteristics
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
