Fabrication and Characterization of Silicate Additive Synthetic Bone Grafts in Defined Geometries

Abstract

In the field of bone tissue engineering, there has still been a great amount of demand on synthetic bone graft that induces differentiation of osteoprogenitor cells by cell-matrix interaction at the nanoscale as well as mimicking micro-assembly of compact bone while providing high mechanical strength. Within the scope of this study, we aimed to develop Synthetic Silicate additive osteoinductive block bone grafts based on beta-tricalcium phosphate in the form of stick, block, and cylinder with tunable porosity, radiopaque and mechanical properties.