Abstract
Self-microemulsifying drug delivery systems are widely used to address water-solubility issues of drug candidates, but with these systems, there is a chance of drug precipitation due to migration of the surfactant in the shell of capsule. Piroxicam is a class II drug that exhibits poor solubility and high permeability. Efforts were made to develop piroxicam self-microemusifying mouth dissolving film using a polymer such as hydroxylpropyl methylcellulose as a film-forming polymer and optimized using response surface methodology of Design-Expert® software version 10. A sublingual self-microemusifying mouth-dissolving film was prepared that disintegrated in 26 seconds. The in vitro drug release of self-microemusifying mouth dissolving film was 98.04±0.016% in 5 min. The newly developed sublingual self-microemusifying mouth dissolving film provided rapid absorption of piroxicam (tmax ~2 h) and suitable for providing a rapid onset of analgesic action.
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