Fabrication and Characterization of Polyelectrolyte Coatings by Polymerization and Co-Deposition of Acrylic Acid Using the Dopamine in Weak Acid Solution.

Abstract

Existing medical materials (such as silicone rubber, glass slides, etc.) fail to meet the functional requirements of biosensing, cell culture, and drug delivery due to their poor wettability. The preparation of polyelectrolyte coatings with excellent wettability and protein adsorption helps broaden the application of medical materials. Poly(acrylic acid) (PAA) is a common polyelectrolyte with stronger protein adsorption, but the existing methods for obtaining PAA coating have certain shortcomings to limit their industrial applications. In this study, dopamine (DA) was used to polymerize and co-deposit acrylic acid (AA) in weak acid solution to functionalize the surface of materials, and the effects of different mass ratios of DA/AA on the wettability and protein adsorption of the coating were deeply investigated. The results demonstrate that PDA/PAA coating is successfully prepared on the surface of four substrates and greatly reduces the water contact angle of these surfaces. Moreover, these coatings show excellent protein adsorption, and the amount of adsorbed protein on the coated QCM chip is increased by 57.74% than the uncoated QCM chip. In addition, the coating has a certain pH responsiveness, and its wettability and protein adsorption are closely related to the pH of the solution. The preparation strategy proposed is simple and substrate-independent, which provides valuable insights into the application of the one-step polymerization and co-deposition strategy under weak acid conditions.