Fabrication and Characterization of Poly (vinyl alcohol) and Chitosan Oligosaccharide-Based Blend Films.

Dilshad Qureshi,Kseniya Hileuskaya,Viktoryia Kulikouskaya,Biswaranjan Mohanty,Preetam Sarkar,Arfat Anis,Ayasharani Sahoo,Vladimir Agabekov,Kunal Pal,Sirsendu Sekhar Ray,Samarendra Maji

doi:10.3390/gels7020055

Abstract

In the present study, we report the development of poly (vinyl alcohol) (PVA) and chitosan oligosaccharide (COS)-based novel blend films. The concentration of COS was varied between 2.5–10.0 wt% within the films. The inclusion of COS added a brown hue to the films. FTIR spectroscopy revealed that the extent of intermolecular hydrogen bonding was most prominent in the film that contained 5.0 wt% of COS. The diffractograms showed that COS altered the degree of crystallinity of the films in a composition-dependent manner. As evident from the thermal analysis, COS content profoundly impacted the evaporation of water molecules from the composite films. Stress relaxation studies demonstrated that the blend films exhibited more mechanical stability as compared to the control film. The impedance profiles indicated the capacitive-dominant behavior of the prepared films. Ciprofloxacin HCl-loaded films showed excellent antimicrobial activity against Escherichia coli and Bacillus cereus. The prepared films were observed to be biocompatible. Hence, the prepared PVA/COS-based blend films may be explored for drug delivery applications.

Highlights

(vinyl alcohol) (PVA) is a thermoplastic synthetic polymer that is prepared either by partial or complete hydrolysis of polyvinyl acetate [1,2,3]
The results showed that the control film exhibited a moderate area under the peak (AUP)
We prepared novel PVA and chitosan oligosaccharide (COS)-based blend films, which were crosslinked with glutaraldehyde

Summary

Introduction

(vinyl alcohol) (PVA) is a thermoplastic synthetic polymer that is prepared either by partial or complete hydrolysis of polyvinyl acetate [1,2,3]. The polymer is readily solubilized in water and its solubility characteristics are dependent on molecular weight, particle size distribution, and crystallinity of the polymer chains [1,2]. Certain factors such as molecular weight, concentration, and hydrolysis degree of PVA have a major effect on the performance of PVA-based polymeric architectures [4]. On the other hand, owing to its certain features like bioinertness and compatibility, PVA has found implications in different medical fields, e.g., drug delivery, hemodialysis, nanofiltration, and implantable medical devices [6,7].

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