Abstract
The particle shape is a key factor influencing drug loading, drug release, cellular interaction, cell uptake, and in vivo distribution of micro- and nanoparticles. The purpose of the study was to develop a preliminary proof of concept about the fabrication of non-spherical particles from spherical nanoparticles by simple film stretching method. The spherical Eudragit® S100 NPs was optimised with various parameters including, the concentration of the polymer, concentration of the surfactants, organic-aqueous phase ratio, and the speed of homogenization. Then, spherical NP-embedded polyvinyl alcohol (PVA) films were stretched to produce non-spherical particles. Finally, the resulting particle size and surface morphology of non-spherical Eudragit® S100 particles were analysed. Dynamic light scattering (DLS), scanning electron microscopy (SEM) and transmission electron microscopy (TEM) have been utilised to analyse the size and morphology of particles, before and after film stretching. The resulting spherical NPs (< 150 nm) were successfully converted into monodispersed non-spherical, rod-like particles (< 500 nm) with precise shape control. The present study provided a simple and economic method for developing non-spherical Eudragit® S100 polymeric particles. These particles could be used as promising colon-specific drug delivery or diagnostic system.
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