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Abstract
In the field of drug delivery, a nebulizer is a device used to convert liquid drugs into tiny airborne droplets, such as aerosol or a mist form. These fine droplets are delivered to a patient’s lungs and airways and then spread throughout the body via blood vessels. Therefore, nebulization therapy is a highly-effective method compared with existing drug delivery methods. To enhance the curative influence of a drug, this study suggests the use of a new micro-porous mesh nebulizer consisting of a controllable palladium–nickel (Pd–Ni) membrane filter, piezoelectric element, and a cavity in the micro-pump. In this research, we optimize a biocompatible Pd–Ni membrane filter, such that it generated the smallest aerosol particles of various drugs. The pore size of the filter outlet is 4.2 μm ± 0.15 μm and the thickness of the Pd-Ni membrane filter is approximately 41.5 μm. In addition, the Pd–Ni membrane filter has good biocompatibility with normal cells. The result of a spray test with deionized (DI) water indicated that the size of a standard liquid droplet is 4.53 μm. The device has an electrical requirement, with a low power consumption of 2.5 W, and an optimal operation frequency of 98.5 kHz.
Highlights
The inhalation of aerosols has played a pivotal role in the vistas of pulmonary drug delivery since ancient times, as a way of relieving respiratory diseases [1,2,3]
Images of each part of the Pd–Ni membrane filter were defined to confirm the direction in which aerosols were moving
The study presented in this paper led to the successful fabrication of a controllable Pd–Ni membrane filter, which is both biocompatible and durable, using lithography and an electroplating process
Summary
The inhalation of aerosols has played a pivotal role in the vistas of pulmonary drug delivery since ancient times, as a way of relieving respiratory diseases [1,2,3]. “aerosol therapy” is medical terminology, which is used to describe a variety of treatment techniques, including the delivery of a variety of drugs that may be administered via inhalation, targeting lung tissues and airway secretions in the upper, central, and peripheral airways [4,5]. These drug-delivery strategies have several advantages compared with conventional methods of oral administration.
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