Fabrication and characterization of magnetic molecularly imprinted polymer based on deep eutectic solvent for specific recognition and quantification of vanillin in infant complementary food

Abstract

A magnetic molecularly imprinted polymer based on deep eutectic solvent was synthesized for specific identification and quantification of vanillin. Fe3O4@SiO2-CC and deep eutectic solvent were applied as the carrier of magnetic material and functional monomer, respectively. According to composition and morphology characterizations and adsorption kinetics, the imprinted polymer had excellent advantages on adsorption capacity and identification specificity for vanillin compared with non-imprinted polymer, while its reusability still remained stable. According to the high-performance liquid chromatography, the detection method based on imprinted polymer produced satisfactory analytical results. The limit of quantification was 0.2 μg·mL−1. The mean spiked recoveries for vanillin ranged from 91.2% to 100.2% with intra- and inter-day precision were both less than 7.2%. Compared to traditional extraction methods, this method presented best adsorption and extraction performances. In summary, the method could be further applied to the specific separation and quantification of vanillin in infant complementary food.