Abstract
In this study, hydrogel films composed of low methoxyl pectin (LMP), gelatin, and carboxymethyl cellulose (CMC) were fabricated. Glycerin was used as a plasticizer while glutaraldehyde (Glu) and calcium chloride (CaCl2) were used as crosslinking agents in film preparation. Hydrogel films were morphologically characterized and evaluated for mechanical properties. In addition, the investigations for fluid uptake ability, water retention capacity, water vapor transmission rate, and integrity value of the invented films were performed. The results showed that F-Glu-Ca-G30 film demonstrated superior properties when compared to other prepared films. It demonstrated a high percentage of elongation at break (32.80%), fluid uptake ability (88.45% at 2 h), water retention capacity (81.70% at 2 h), water vapor transmission rate (1889 g/m2/day), and integrity value (86.42%). F-Glu-Ca-G30 film was subsequently selected for 10% w/w povidone iodine (PI) loading and tested for anti-Staphylococcus aureus activity using an agar diffusion assay. Notably, F-Glu-Ca-G30-PI film demonstrated a dramatic ability to inhibit microbial growth, when compared to both a blank film and iodine solution control. Our LMP/gelatin/CMC hydrogel film promises to be an effective dressing material with high fluid absorption capacity, fluid holding ability, and water vapor transmission rate. Incorporation of antibiotics such as povidone iodine into the films conferred its antimicrobial property thereby highlighting its potential dermatological use. However, further clinical studies of the application of this hydrogel film as wound dressing material is recommended.
Highlights
Numerous wound dressing materials are available and are being investigated [1,2,3].The desirable wound dressing may serve among various purposes, such as providing moisture and occlusion, and protect from infections and contamination [4,5,6]
Low methoxyl pectin (LMP)/gelatin/carboxymethyl cellulose (CMC) hydrogel films were prepared by a solvent casting method using Glu and
films using Glu (F-Glu)-Ca-G40 exhibited slightly lower on tensile strength and Young’s modulus with higher percentage of elongation when compared to F-Glu-Ca-G30, and no significant difference was found between them. This result suggested that addition of 30% w/w glycerin was enough to generate a flexible LMP/gelatin/CMC hydrogel film, by improving its mechanical properties
Summary
Numerous wound dressing materials are available and are being investigated [1,2,3]. The desirable wound dressing may serve among various purposes, such as providing moisture and occlusion, and protect from infections and contamination [4,5,6]. When in contact with wound exudates, hydrogel has an immediate reaction to form gels and high fluid absorption occurs via strong hydrophilic gel formation [8]. Materials 2019, 12, 1628 to maintain its three-dimensional structure, the hydrophilic polymer chains are cross-linked either by covalent or non-covalent bonds, i.e., electrostatic, hydrophobic, or van der Waals interactions [9].
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