Abstract
Introduction: Nanofiber (NF) represents one of the newest, promising and advanced technologies in transdermal and or mucosal drug delivery due to its unique advantages. The present study aims to explore the feasibility of Kollidon® SR (K-SR) to fabricate sustained release Eprosartan (EPR) loaded nanofiber (NF) by using electrospinning technology for transdermal drug delivery. The EPR-NF mat was prepared with sodium iodide (SI) along the backing membrane and compared with film cast mat. The fabricated NF mechanical and physicochemical properties were assessed. Further, NF evaluated for in-vitro and ex-vivo diffusion study, skin irritation study and for antihypertensive activity.
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