Abstract
Polymer blending is a method to provide nanocomposite nanofibers with improved strength and minimal defects. Chitosan exhibits biocompatibility, biodegradability, antimicrobial activity, and wound healing properties. A combination of gelatin and thermoplastic polyurethane (TPU) blends was explored as a means to improve the morphological deficiencies of chitosan nanofibers and facilitate its electrospinnability. The morphology of the electrospun chitosan, chitosan/gelatin, and chitosan/gelatin/TPU blend nanofibers were characterized using scanning electron microscopy (SEM), while the miscibility and thermal behavior of the blends were determined using differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy/attenuated total reflectance (FTIR/ATR). The optimum results were achieved in blend with 3 wt% chitosan, 8 wt% gelatin, and 5 wt% TPU, which resulted nanofibers with a mean diameter of 100.6 nm ± 17.831 nm.
Highlights
Nanofibers from biocompatible polymers have demonstrated prospective applications in biomedicine, including wound dressings,[1] drug delivery,[2] tissue engineering scaffolds,[3] and many more
Understanding the behavior of such nanofibers in this new process is of utmost significance, and this work examines the morphology and miscibility and thermal behavior of nanofibers using scanning electron microscopy (SEM), Fourier transform infrared spectroscopy/attenuated total reflectance (FTIR/ATR), and differential scanning calorimetry (DSC) techniques
There are some peculiar peaks that appear for pure chitosan and gelatin to explain their special properties
Summary
Nanofibers from biocompatible polymers have demonstrated prospective applications in biomedicine, including wound dressings,[1] drug delivery,[2] tissue engineering scaffolds,[3] and many more. The main objective of this work was to study the fabrication possibility of gelatin/chitosan/TPU blend nanofibers.
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