Fabrication and Characterization of Chitosan and Pectin Nanostructured Multilayers

Abstract

Chitosan has been used for drug delivery applications for many years, and pectin has been recently used for several biomedical applications too. Both chitosan and pectin have shown to possess mucoadhesive properties. We report the assembly and characterization of biocompatible and biodegradable multilayers based on the layer-by-layer (LbL) deposition of chitosan and pectin. The dependence of the multilayer properties on the degree of esterification of pectin, as well as on the assembly pH, is characterized, and the mucoadhesiveness of the multilayers is estimated at oral and gastric pHs. The LbL assembly of chitosan and pectin for the fabrication of hollow capsules is carried out for the first time, and its potential use for drug delivery applications opens new prospects for the production of novel drug delivery materials.