Fabrication and characterization of a gum ghatti-cl-poly(N-isopropyl acrylamide-co-acrylic acid)/CoFe2O4 nanocomposite hydrogel for metformin hydrochloride drug removal from aqueous solution

Abstract

Hydrogels are desirable biomaterials because of their innovative organization structure, which allows them to function with a wide range of hydrophilicity and biocompatibility. Hydrogels, on the other hand, possess sensitive physical characteristics when coupled with live tissue. In the current work, metformin hydrogen chloride (metformin HCl)- loaded the original [Gum ghatti-cl-Poly(N-isopropyl acrylamide-co-acrylic corrosive)/CoFe2O4] nanocomposite hydrogel were orchestrated through the free extreme polymerization strategy utilizing ammonium persulfate (APS) as initiator and N, N′-methylene bis-acrylamide (MBA) as a cross-connecting specialist to eliminate the metformin hydrochloride drug from watery arrangements. The influence of numerous parameters on the amount of adsorbate, including pH, temperature, equilibrium time, and adsorbate weight, was investigated, and the ideal conditions for preparing adsorbate were determined. The hydrogel was characterized using FTIR, XRD, AFM, FESEM, and TGA methods. Three powerful models viz. pseudo-first order, pseudo-second order, and intraparticle scattering model, were used and fitted to the equilibrium data to choose the adsorption part of metformin adsorption onto Gg-cl-poly(NIPA-co-AA)/CoFe2O4 nanocomposite hydrogel. The adsorption isotherm information was explored with the assistance of four isotherm models viz. Langmuir, Freundlich, Temkin and Dubinin-Radushkevich (DRK) isotherms. The metformin adsorption process followed the pseudo-second-order model and Langmuir adsorption isotherm with a most extreme adsorption limit of 151.07 ​mg/g. To investigate the adsorption nature and promptness metformin, a couple of thermodynamic limits were estimated and observed that the adsorption system is exothermic and unconstrained.