Abstract
The indium gallium zinc oxide (IGZO) was adopted as enzymatic glucose sensing membrane and a screen-printed technology was used to complete fabrication of sensor in this paper. There are some drawbacks for most of the enzymatic glucose biosensors, such as insufficient sensing area and weak immobilization strength, formed between glucose oxidase (GOx) and support materials. For improving drawbacks of enzymatic glucose biosensor, graphene oxide (GO) was directly dropped on the IGZO sensing membrane to improve sensing area and magnetic beads (MBs) were combined with GOx by covalent bonding to enhance immobilization strength for GOx. In addition, the enzymatic glucose biosensor modified by GO and MBs was integrated with microfluidic framework in order to investigate sensing characteristics under the dynamic conditions. According to the experimental results, the optimal average sensitivity and linearity of the enzymatic glucose biosensor were 12.383 mV/mM and 0.999 at 25- $\mu \text{L}$ /min flow rate, respectively.
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