Abstract
Objective: An attempt has made in fabricating solid dispersions (SDs) by taking lercanidipine hydrochloride (LCD) as a model drug.
 Methods: The SDs were made using a poly mix of poly vinyl pyrrolidone (PVP) K-30, Poloxamer-188, and hydroxy propyl methyl cellulose (HPMC) K4M. Different proportions of LCD: polymer mix in 1:1, 1:3, 1:5, and 1:7 ratios were fabricated as SDs by solvent evaporation and melting method, further compressed into tablets. The LCD SDs were assessed for physicochemical, and LCD release possessions.
 Results: The results were observed to be attractive with the increase in solubility LCD SD (F-3 and F-7) with 1:5 ratios of LCD.
 Conclusion: The study concludes that the poly mix of PVP K-30, Poloxamer-188, and HPMC K4M and was found to be a better combination for elevating the solubility and release of LCD from the SDs.
Highlights
The oral route is ideal, for its ease of handling and intake by patients of all ages [1]
The study concludes that the poly mix of poly vinyl pyrrolidone (PVP) K-30, Poloxamer-188, and hydroxy propyl methyl cellulose (HPMC) K4M and was found to be a better combination for elevating the solubility and release of Lercanidipine hydrochloride (LCD) from the solid dispersions (SDs)
Designing of SDs Melting The polymers were melted on their melting point basis (HPMC-K4M, PVP K-30, Poloxamer-188) in a porcelain dish; later LCD was dispersed in the formed mass with continual blending [7]
Summary
The oral route is ideal, for its ease of handling and intake by patients of all ages [1]. Solubility and dissolution are vital constraints for drugs with poor solubility [2]. Formulation scientist makes several attempts to resolve the issues related to solubility. Various approaches were made to elevate the drug solubility, among them solid dispersions (SDs) approach positioned on the peak [3], as it is a simple, easy, and efficient tactic in increasing solubility. LCD is prescribed for hypertension and angina patients. The poor aqueous solubility of LCD restricts the onset of action [5]. The antihypertensive action of LCD is because of a direct relaxing of vascular smooth muscle which lowers total peripheral resistance and blood pressure [6]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
