Abstract
In the present study, the ability of porous silicon (PSi) based distributed Bragg reflector (DBR) microparticles for sustained and observable delivery of the antiviral agent acyclovir (ACV) is demonstrated. DBR was fabricated by electrochemical etching of single crystal silicon wafers and ultrasonic fractured to prepare microparticles. The hydrogen-terminated native surface of DBR microparticles was modified by thermal oxidation and thermal hydrosilylation. Particles were loaded with ACV and drug release experiments were conducted in phosphate buffered saline. Drug loading and surface chemistry of particles were characterized by scanning electron microscopy and Fourier transform infrared spectroscopy. Drug release profiles from PSi DBR particles show sustained release behavior from all three studied surface chemistries. Drug release from particles was also monitored from change in color of particles.
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