Abstract
Fluorescent magnetic nanoparticles (NPs) utilized for imaging hold great promise for biomedical applications, but it remains a challenging task. Here, we report novel dual-modality NPs using an aggregation-induced emission (AIE)-active and near-infrared (NIR) emissive dye (TPAS) and magnetic Fe3O4 as the core, and biocompatible polymer Pluronic F-127 as the encapsulation matrix by self-assembly procedures. The obtained fluorescent-magnetic AIE NPs have both high fluorescence quantum yield (13.8%) at 700 nm and high magnetic saturation value. With good photostability and biocompatibility, the resulting NPs show effective MRI ability, but also a stain in cytoplasm with a strong NIR fluorescent signal.
Highlights
As a noninvasive imaging technology, magnetic resonance imaging (MRI) possesses high spatial resolution and desired tissue penetration depth, but it suffers from low sensitivity and resolution [1,2].On the other hand, fluorescence imaging has high sensitivity but fails to provide quantitative evaluation [3]
The integration of MRI and fluorescence imaging into a single probe will afford multimodal probe with synergistic benefits, which is highly desirable in bioimaging and diagnosis and provide more effective and accurate information about physiological functions [4,5,6,7,8,9,10]
The bromic group of 4-bromo-N,N-di-para-tolylaniline was shown in Figure 1a, NIR fluorophore
Summary
As a noninvasive imaging technology, magnetic resonance imaging (MRI) possesses high spatial resolution and desired tissue penetration depth, but it suffers from low sensitivity and resolution [1,2]. Fluorescence imaging has high sensitivity but fails to provide quantitative evaluation [3]. The integration of MRI and fluorescence imaging into a single probe will afford multimodal probe with synergistic benefits, which is highly desirable in bioimaging and diagnosis and provide more effective and accurate information about physiological functions [4,5,6,7,8,9,10]. Near-infrared (NIR; 650–900nm) fluorescent probes have attracted intense interest due to less damage to living cells, better tissue penetration, improved the image sensitivity and lower interference from background auto-fluorescence.
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