FABRICATION & CHARACTERZATION OF DUAL CROSS LINKED PULSATILE BEADS OF DIACEREIN USING NATURAL GUM

Abstract

In the present study, pulsatile dual cross linked beads were prepared by ionotropic gelation method. Diacerein dual crossed linked beads were prepared by dropping dispersed phase of diacerein (DcN), Moringa olifera gum and sodium alginate into dispersed phase of different concentration of calcium chloride solution followed by 5% & 10% Aluminum chloride solution and 2% sodium tripolyphosphate (TPP) solution. In vitro release studies showed lag time of 3-7 h before the release of diacerein from the formulated beads, which were found to be intact for 5 h. Thus, formulated dual cross linked beads when administered at morning time may release the drug when needed most for chronotherapeutics of osteoarthritis in chronic patients.