Abstract
Nanostructured surfaces of porous scaffolds can imitate the hierarchical pore space architecture of bone tissue, thus playing a critical role in bone regeneration. In this work, hydrothermal treatment was exploited to construct nanostructured surfaces of the porous CaSiO3 scaffolds fabricated by selective laser sintering (SLS). The rod- or sheet-like hydroxyapatite (HAp) nanostructured surfaces were controllably constructed via using different hydrothermal reaction solution. And nanostructured surfaces possessed high specific surface area, which provided more adsorption sites for cell adhesion and migration. Simultaneously, the biomimetic features of the hierarchical nanostructure effectively promoted cell proliferation and differentiation. Moreover, the nanostructured surfaces decelerated the overquick degradation of the scaffolds due to the slower degradation rate of HAp than that of CaSiO3. Besides, the scaffolds maintained stable mechanical properties even after hydrothermal treatment.
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