Abstract
A nanostructure composed of Anodic Aluminum Oxide (AAO) was obtained on an electrode of a quartz crystal microbalance (QCM) chip by anodizing Al thin film in an oxalic acid solution. The effective surface area was expanded by these nanostructures. Several morphologies were observed under various anodic conditions by using scanning electron microscopy (SEM). We demonstrated that a QCM chip with the AAO was effective in biosensing because of its large surface area. The frequency shift corresponding to an antigen-antibody reaction improved on the nanostructured electrode compared with a flat surface electrode.
Highlights
In the recent years, many biosensing systems, for examples, surface plasmon resonance (SPR)and enzyme-linked immune sorbent assay (ELISA) are widely used
The surface area was enlarged by nanostructures, and the amount of analyte binding on the surface was greatly improved
The result indicates that sensitivity of the anodic aluminum oxide (AAO) nanostructured quartz crystal microbalance (QCM) chip was improved by the nanostructure and the obtained frequency shift was 10 times larger than that on the flat surface
Summary
Many biosensing systems, for examples, surface plasmon resonance (SPR). Some conditions are required for biosensing as follows; low cost equipment, rapid analysis, real time measurement, high sensitivity and convenient protocol. If these requires are achieved, we can perform biosensing system . QCM method is one of promising approaches to detect gas molecules and bio materials It has advantages in real time measurement, high sensitivity, and portability. The method has poor sensitivity to low molecular weight materials (
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