FABP4 and omentin-1 gene expression in epicardial adipose tissue from coronary artery disease patients.

Valentina V Miroshnikova,Sofya N Pchelina,Diana A Kolodina,Aleksandra A Panteleeva,Irina A Pobozheva,Elena I Baranova,Olga D Belyaeva,Olga A Berkovich,Natalia D Razgildina,Ekaterina A Polyakova

doi:10.1590/1678-4685-gmb-2020-0441

Abstract

Omentin-1 and fatty acid-binding protein 4 (FABP4) are adipose tissue adipokines linked to obesity-associated cardiovascular complications. The aim of this study was to investigate epicardial adipose tissue (EAT) omentin-1 and FABP4 gene expression in obese and non-obese patients with coronary artery disease (CAD). Omentin-1 and FABP4 mRNA levels in EAT and paired subcutaneous adipose tissue (SAT) as well as adipokine serum concentrations were assessed in 77 individuals (61 with CAD; 16 without CAD (NCAD)). EAT FABP4 mRNA level was decreased in obese CAD patients when compared to obese NCAD individuals (p=0.001). SAT FABP4 mRNA level was decreased in CAD patients compared to NCAD individuals without respect to their obesity status (p=0.001). Omentin-1 mRNA level in EAT and SAT did not differ between the CAD and NCAD groups. These findings suggest that omentin-1 gene expression in adipose tissue is not changed during CAD; downregulated FABP4 gene expression in SAT is associated with CAD while EAT FABP4 gene expression is decreased only in obesity-related CAD.

Highlights

Adipose tissue produces adipokines, and any abnormality in their expression and secretion can play a role in the development of obesity-associated diseases (Ntaios et al, 2013; Lau et al, 2017)
We show that fatty acid-binding protein 4 (FABP4) mRNA expression was downregulated in subcutaneous adipose tissue (SAT) of patients with coronary artery disease (CAD)
FABP4 is known to be expressed by the macrophages in adipose tissue as well as those from atherosclerotic plaques (Agardh et al, 2011; Furuhashi et al, 2016)

Summary

Introduction

Any abnormality in their expression and secretion can play a role in the development of obesity-associated diseases (Ntaios et al, 2013; Lau et al, 2017). Previous studies have proposed the imbalance in adipokine secretion in obesity, metabolic syndrome, diabetes, hypertension, atherosclerosis and cardiovascular disease (Lau et al, 2017). EAT volume is associated with atherosclerotic lesions in the coronary arteries and severity of CAD, as well as fatal and nonfatal coronary events in the general population, regardless of the presence of traditional risk factors of cardiovascular disease, such as smoking, obesity, dyslipidemia and diabetes mellitus (Iacobellis, 2015)

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