Abstract

In order to improve the degradation rate of silica framework and the targeted release ability of tumor drugs, this paper used a one-pot synthesis method to synthesize a redox with a silsesquioxane framework disulfide bridge and a particle size of about 150 nm. The triggered biodegradable organic-inorganic hybrid nanocapsule is a new and unique hollow mesoporous nanocapsule that is sequentially coupled with bovine serum albumin (BSA) and folic acid (FA) for the targeted release of adriamycin. As a “control gate”, BSA can prevent the premature release of drugs until the BSA coating “opens the door” in response to Glutathione(GSH) to achieve drug release. FA specifically recognizes the folate receptor on the tumor surface to achieve tumor targeting. Under acidic PH and GSH, it can achieve accelerated and complete release of drugs, and effectively consume intracellular GSH, help break the redox barrier in hypoxic cells, cause oxidative stress, and effectively inhibit tumor growth.

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