Abstract
Medial prefrontal cortex (mPFC) activity is necessary for the rapid antidepressant effects of ketamine. The mPFC is comprised of multiple pyramidal neuron subtypes but their individual role in the antidepressant response in unclear. The current study addresses this issue using transgenic mice that express Cre recombinase under the control of the dopamine Drd1 or Drd2 promoters to target viral constructs to pyramidal neuron subtypes in an attempt to elucidate their role in rapid antidepressant responses.
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