Abstract
Recent work has demonstrated that low-dose penicillin treatment of mice during pre- and early post-natal periods has long-term effects on offspring behavior, brain neurochemistry and microbiome (Leclercq et al 2017), many of which are prevented by concurrent treatment with a probiotic. We have now observed that low-dose penicillin during adolescence results in long-term behavioural change. Adolescence is a vulnerable period in brain development, and a time in humans when psychiatric illness often first manifests. While processing of olfactory cues is recognized as integral to rodent behavior, this is often neglected in such studies. We therefore examined the impact of low-dose penicillin treatment during adolescence on social odour discrimination.
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