F41 - Prognostic role of pregnancy in breast cancer patients. a single institution experience

Abstract

The prognostic role of pregnancy occurring before or after a breast cancer diagnosis is still unclear. Data of young women with breast cancer and pregnancy treated from 2002 and 2014 in our institution were retrospectively analyzed and compared with data of patients with breast cancer not associated with pregnancy. The aim of the study was to evaluate the role of pregnancy on the prognosis of these patients. The main analysis was performed using Kaplan Meyer curves for DFS and OS and Log-rank test to evaluate differences between the two groups. They were matched for the following prognostic markers: age, histology, grade, hormone receptor status, human epidermal growth factor 2 status, BRCA1or BRCA 2 mutations, type of chemotherapy and use of trastuzumab, radiotherapy and hormonal therapy. The first group consisted of 40 patients with breast cancer and pregnancy of whom 6 patients with breast cancer during pregnancy, 7 patients with cancer during breast feeding and 27 patients with breast cancer after pregnancy (< 5 years). The non pregnant group consists in 83 women. Median age was 44 years for the pregnant and 37 years for the non pregnant patients. Median follow up was 37.5 mos. Median DFS of pregnancy group was not reached, 54,7% of the patients is disease free at 154 months, median DFS of non pregnancy group was 97 months, CI 95% (82-111), p = 0,27. There were not statistical differences in DFS for estrogen receptor positive, Her 2 positive and triple negative subgroups between the two cohorts. No deaths were observed within the two groups. In conclusion, although our analysis shows some limitations such as a small sample size and a short follow up, we found similar outcome for patients with primary breast cancer diagnosed during pregnancy when compared with non pregnant patients with breast cancer. In line with previous reports we found no evidence that a pregnancy during or after breast cancer has a negative role for prognosis.