Abstract
BackgroundIndividuals with psychotic symptoms often report low global self-esteem (GSE).However, it remains unclear whether the low GSE is linked to the presence of psychotic symptoms or it is present prior to the onset of psychosis. Additionally, the specific subdomains of GSE in these populations are unknown.MethodsTo address this question, we conducted a cross-sectional study comparing global and SE elements among individuals at clinical high-risk for psychosis (CHR; n=36), individuals with schizophrenia (SCZ; n=43), and healthy controls (HC; n=40). We then examined among CHR individuals the association between GSE, subdomains, and symptoms.ResultsCHR individuals displayed significantly lower GSE compared to HC, at a level comparable to individuals with SCZ. The low GSE was driven primarily by self-perceptions of work and interpersonal relationships abilities, in the sub-domains of provider (r=.53, p<.001), physical appearance (r=.37, p=.026), sense of humor (r=.45, p=.006), intimate relations (r=.45, p=.006), and job competence (r=.39, p=.018). Lower GSE was associated with overall negative (p<0.01) and disorganized (p<0.05) symptoms severity, but not positive ones.DiscussionThis investigation demonstrates that low self-esteem, which is prevalent in SCZ, is also present to a comparable degree of severity in CHR individuals. Our findings help to better understand the CHR period and may suggest targets for early psychosocial treatments aimed at improving social and occupational functioning, as such domains appear to play an important role in determining GSE in this population. The examination of different dimensions of self-esteem in the assessment of CHR populations may contribute to a better understanding of the phenomenology of prodromal symptoms, and thus, may have implications for finding successful early therapeutic approaches, rehabilitation, and social integration for a condition that is accompanied by considerable suffering and risk of suicide.
Highlights
Individuals with psychotic symptoms often report low global self-esteem (GSE)
We examined among clinical high-risk for psychosis (CHR) individuals the association between GSE, subdomains, and symptoms
Administration of subanaesthetic doses of the NMDA receptor antagonist ketamine provides a translational model of schizophrenia, modifying neuronal activity in brain networks underlying the symptoms of the disorder
Summary
S233 antipsychotic medication in the year were investigated for the prescribed medication and concomitant psychotropic medication. Results: A total of 91 children and adolescents (mean age 16.2 ± 2.2 years, 53 boys) received antipsychotic medication. Risperidone (n = 59, 35.3%) and aripiprazole (n = 34, 20.4%) were the two most frequently prescribed antipsychotics. Of 91 patients, 80 (87.9%) have prescribed with antipsychotic monopharmacy (mean 134.9 ± 11.1 day), 33 (36.3%) with bipharmacy (mean 136.9 ± 20.2 days), and 12 (13.2%) with polypharmacy (more than three antipsychotics) (mean 32.5 ± 7.3 days) in the year. Mood stabilizers (n=48, 52.7%), and antidepressants (n=35, 38.5%) were co-medicated in the year. Discussion: Our study shows the prescription pattern of antipsychotics for children and adolescents with schizophrenia in Korea. SELF-ESTEEM AND SYMPTOMS IN INDIVIDUALS AT CLINICAL HIGH-RISK FOR PSYCHOSIS. Caridad Benavides*,1, Gary Brucato, David Kimhy1 1Icahn School of Medicine at Mount Sinai; 2Columbia University
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