F29Vascular network in LUF syndrome

Abstract

BackgroundThe principal aim was to reveal additional information and comprehension's on physiology of the normal and pathophsysiology of disturbed cycles, that may lead towards the new diagnostic approaches and treatments in infertile patients.MethodThe group of 22 patients included women with LUF syndrome. The emphasis was put on the intraovarian vascularity and especially on vascularity from inner vessels of ring of the follicle. Scans were performed on 5th, 10th, 12th, 21st and 24th day of menstrual cycle. A control group of 38 patients with regular menstrual cycles was selected on the basis of the normal gynecological, sonographical and hormonal findings. These patients had normal ovulatory cycles but were investigated for infertility due to the male factor.ResultsDoppler studies of the uterine artery and its evaluated branches have suggested significant decrease of the velocities at 12th and 15 h day of MC compared to control group. The RI of ovarian artery were around 0.84 ± 0.016 during the MC and excepted lowering of the RI has not occurred during the preovulatory period as in the control group. Velocity of ovarian artery of the dominant side showed significantly lower values, with the mean values of 34 cm/s ± 1.1 in the patients with LUF sy. compared to controls. The development of the RI of the intraovarian stromal vessels in LUF sy. were similar to that of anovulatory cycles, showing the loss in the cycling rhythm and post peak LH values similar to those of the follicular growth phase.ConclusionThe results of this study showed again that there is clear relationship between hormone mediators, primarily the steroids and velocimetric indices taken during the observed cycles. It also would seem that the hormones, with its mediators and hemodynamic factors play an important role through systemic and local action, in regulating uterine and ovarian blood flow.