Abstract
Obsessive-Compulsive Disorder (OCD) is a debilitating neuropsychiatric disorder that is known to be moderately heritable but has poorly understood pathogenesis, limiting development of novel pharmacologic treatments. Previous studies suggest a significant contribution to OCD risk from de novo germline variants, which arise spontaneously in the parental germ cells or zygote. Recent studies of autism spectrum disorder and intellectual disability suggest a risk contribution from post-zygotic variants (PZVs) arising de novo in multicellular stages of embryogenesis, suggesting these mosaic variants can be used to examine the genetic underpinnings of other neuropsychiatric disorders such as OCD.
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