F236. Association of Baseline Tumor Necrosis Factor and the Development of Negative Symptoms in Individuals at Clinical High Risk for Psychosis

David Goldsmith,Andrew Miller,Jean Addington,Carrie Bearden,Kristin Cadenhead,Tyrone Cannon,Barbara Cornblatt,Daniel Mathalon,Thomas Mcglashan,Diana Perkins,Ming Tsuang,Scott Woods,Elaine Walker

doi:10.1016/j.biopsych.2018.02.850

F236. Association of Baseline Tumor Necrosis Factor and the Development of Negative Symptoms in Individuals at Clinical High Risk for Psychosis

David Goldsmith, Andrew Miller + Show 11 more

https://doi.org/10.1016/j.biopsych.2018.02.850

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Journal: Biological psychiatry

Publication Date: Apr 9, 2018

Affiliation: Emory University, University of Calgary, University of California, Los Angeles, California Western School of Law, Yale University, Zucker Hillside Hospital, University of California, San Francisco, University North

#North American Prodromal Longitudinal Study #Clinical High Risk For Psychosis + Show 8 more

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Abstract

Negative Symptoms are core symptoms of schizophrenia and other psychotic disorders. Understanding predictors of negative symptoms in the clinical high-risk (CHR) state of psychosis is necessary to investigate risk factors for these symptoms. Previous work from the North American Prodromal Longitudinal Study (NAPLS) cohort has demonstrated that inflammation may be related to the development of psychosis in CHR subjects, which supports a literature showing an association between inflammation and psychopathology of schizophrenia, including negative symptoms.

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