Abstract
Persons exhibiting clinical high-risk (CHR) symptoms similar to but milder than those of schizophrenia have an elevated risk of developing this disorder. We sought evidence that CHR patients process relationships between meaningful concepts abnormally, similar to what has been observed in schizophrenia, and that these abnormalities are related to psychosis-like symptoms. To probe how meaningful stimuli activate related concepts in semantic memory, we measured the N400 event-related potential (ERP) response. We hypothesized that the normal reduction in N400 amplitude for stimuli that are more related to a preceding one is decreased in CHR patients, and that this abnormality correlates with psychosis-like symptoms.
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