F206. Neural Mechanisms Guiding Choices for Cannabis and Alternative Rewards in Cannabis Smokers

Gillinder Bedi,Xuejun Hao,Anna Konova,Nicholas Van Dam,Paul Glimcher,Margaret Haney

doi:10.1016/j.biopsych.2019.03.743

F206. Neural Mechanisms Guiding Choices for Cannabis and Alternative Rewards in Cannabis Smokers

Gillinder Bedi, Xuejun Hao + Show 4 more

https://doi.org/10.1016/j.biopsych.2019.03.743

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Journal: Biological Psychiatry

Publication Date: May 1, 2019

Affiliation: University of Melbourne, Royal College of Physicians, Rutgers, The State University of New Jersey, New York University, Columbia University Irving Medical Center

#Preferred Snacks #Experimental Medicine Approach + Show 8 more

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Abstract

Substance misuse is characterised by persistent choices for drugs over other rewards. Neural mechanisms underpinning drug-biased choice in humans are poorly understood. Using an experimental medicine approach, we investigated subjective value (SV) encoding during choices for cannabis and a natural reward (individuals’ preferred snacks) in regular cannabis smokers. Effects of cues (cannabis, snack, or neutral) were also assessed.

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