Abstract
Metabolic Syndrome (MetS), a constellation of major cardiovascular risk factors, is highly prevalent in mental illness, thereby increasing morbidity and mortality. NO/nitrite pathways have been previously associated with obesity/metabolic syndrome but the direction of association remains inconsistent, probably due to sample heterogeneity. We now hypothesized that, in the Old Order Amish, a relatively homogeneous population, nitrite levels will be higher in obesity and MetS.
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