Abstract
BackgroundThought disorder (TD) is an important symptom that demonstrates familial aggregation, predicts conversion to psychosis in those at risk, and predicts the duration and rate of hospitalisation in those with psychosis. However, the aetiology of TD is debated, with theoretical accounts revolving around executive, language, and semantic impairments. The aim of the current systematic review was to synthesise the research that has investigated TD using task-based functional neuroimaging techniques to target executive, language, or semantic functions.MethodsThe literature search was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement. The databases: PubMed, Scopus, and Web of Science were used to locate relevant literature from January 1990 to August 2016. The search strategy was broad and inclusive to capture exploratory and secondary TD-related analyses.ResultsThe search yielded 5821 records, from which 37 pertinent studies were identified. Functional correlates of TD included the superior and middle temporal, fusiform, and inferior frontal gyri bilaterally, as well as the left and right cingulate cortex, the right caudate nucleus, and the cerebellum. TD-related increases and decreases in activation were both evident in most of these regions. However, the specificity of these correlates from general clinical and cognitive influences, as well as the relationships between task-based function and behavioural performance, are currently unknown.DiscussionThe cortical regions implicated overlap with those thought to contribute to language and semantic systems. Cortico-striatal circuitry may additionally play a role in some aspects of TD through aberrant salience representation and inappropriate attentional prioritisation. To advance the field further, greater integration across structural, functional, and behavioural measures is required, in addition to non-unitary considerations of TD and more thorough investigations of component cognitive processes.
Highlights
Poster Session IIF151. A SYSTEMATIC REVIEW OF TASK-BASED FUNCTIONAL NEUROIMAGING STUDIES IN THOUGHT DISORDER Philip Sumner*,1, Imogen Bell1, Susan Rossell2 1Swinburne University of Technology; 2Monash Alfred Psychiatry Research Centre, The Alfred Hospital and Monash University, Central Clinical School, Swinburne University of Technology, The University of Melbourne, St. Vincent’s Hospital
Thought disorder (TD) is an important symptom that demonstrates familial aggregation, predicts conversion to psychosis in those at risk, and predicts the duration and rate of hospitalisation in those with psychosis
Functional correlates of TD included the superior and middle temporal, fusiform, and inferior frontal gyri bilaterally, as well as the left and right cingulate cortex, the right caudate nucleus, and the cerebellum
Summary
F151. A SYSTEMATIC REVIEW OF TASK-BASED FUNCTIONAL NEUROIMAGING STUDIES IN THOUGHT DISORDER Philip Sumner*,1, Imogen Bell1, Susan Rossell2 1Swinburne University of Technology; 2Monash Alfred Psychiatry Research Centre, The Alfred Hospital and Monash University, Central Clinical School, Swinburne University of Technology, The University of Melbourne, St. Vincent’s Hospital
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
