Abstract
BackgroundNeuroimaging techniques have been developed as important tools to investigate brain dysfunctions that underlie mental disorders. In particular, modern functional magnetic resonance imaging (fMRI) holds the promise to provide neurofunctional biomarkers for improved diagnosis, prognosis, and optimized treatment of schizophrenic and affective disorders.MethodsNeurofunctional connectivity MRI using advanced experimental paradigms permits targeted investigation of the functional integrity of brain systems involved in the pathomechanisms of schizophrenic and affective disorders. From these investigations, pathophysiologically relevant neuroimaging biomarkers can be derived for differential diagnosis and tailored treatment selection.ResultsPossible neuroimaging biomarkers will be presented for the prediction of development and clinical course of schizophrenic and affective disorders as well as for the prediction of individual treatment responses. Further, recent neuroimaging findings on possible pathophysiological subtypes of schizophrenic and affective disorders will be discussed.DiscussionThese findings from functional neuroimaging studies may help to foster the development of precision medicine in psychiatry.
Highlights
Neuroimaging techniques have been developed as important tools to investigate brain dysfunctions that underlie mental disorders
Neurofunctional connectivity MRI using advanced experimental paradigms permits targeted investigation of the functional integrity of brain systems involved in the pathomechanisms of schizophrenic and affective disorders
Data were taken from a COMT genotype and response to cognitive remediation study of schizophrenia in the United States conducted between 07/2005 and 10/2015 for inpatients with schizophrenia who were participating in psychiatric rehabilitation
Summary
S275 guidance on physicians’ responsibilty when it comes to risk of psychological harm to a potential targeted victim Methods: This case report illustrates a clinical dilemma on duty to warn for mental health professionals. Results: N/A Discussion: This case report illustrates an unconventional perspective on a psychiatrist’s duty to warn: consideration of risk of psychological harm to the potential target of their patient. Psychological trauma can have a potential negative impact on victims, affecting their mental health and well being as well as their physical health. The ethicolegal dilemma discussed in this case has implications for policies related to the care of psychiatric patients. THE USE OF NEUROIMAGING MARKERS IN STRATIFIED DIAGNOSIS AND THERAPY OF SCHIZOPHRENIC AND AFFECTIVE DISORDERS
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