Ezrin and Podoplanin Expressions Are Associated in Invasion Front of Lip Cancer

Agnes Assao,Denise Tostes Oliveira,Alexandre Simões Garcia,Suely Nonogaki,José Roberto Pereira Lauris,Cleverson Teixeira Soares,Kellen Cristine Tjioe

doi:10.1016/j.oooo.2014.07.345

Abstract

Introduction Human podoplanin has a role in the invasion process of the epithelial malignant cells and its upregulation is correlated with poor prognosis in patients with head and neck cancer. The cytoplasmic tail of the podoplanin can bind to ezrin, a protein that has been associated with metastasis and lower survival rate in patients with oral cancer. The aim of this study was to evaluate the association between podoplanin and ezrin immuneexpressions by the cells of the invasive tumour front in the lip cancer. Materials and methods

Highlights

The anatomy of the head and neck is unique and complex
Since the oral cavity and the aero-digestive tracts are accessible to direct examination it is feasible that disease process can be detected at an early stage
The results showed 92% sensitivity and 60% specificity in detecting high grade dysplasia or cancer

Summary

Introduction

The anatomy of the head and neck is unique and complex. since the oral cavity and the aero-digestive tracts are accessible to direct examination it is feasible that disease process can be detected at an early stage. The overall conclusion was that the Society is growing and becoming known worldwide and have a great wealth in its members of clinical academics and scientists This society will continue to dedicate itself to helping develop optical diagnostic techniques in the head and neck and provide training networks for the exchange of information and education. The second session was highlighted by 3 lectures by Jerjes W on the clinical applications of elastic scattering spectroscopy in head and neck, Witjes M on single fiber reflectance measurements of cervical lymph nodes for identifying metastasis from oral carcinoma and a very interesting lecture by Cook R on micro-vascularoscopy and discussed its applications as a valuable technique for localised optical tissue assessment. The HNODS Council welcomed Dr Jennifer Rosen and Dr Arjen Amelink as new Council Members

11. Discussion

Findings

12. Conclusions

24. Webb RH