Abstract
We report a case of a 21-year-old male patient who underwent corneal cross-linking (CXL) due to bilateral progressive keratoconus. Topographical screening of his family members was performed for the detection of possible familial keratoconus and showed abnormal topographical patterns resembling to Forme Fruste Keratoconus (FFK) in all the members of his family. The reported keratoconic patient that underwent CXL was the only individual of this family that referred eye rubbing in his personal ocular history; ocular and medical history of the other family members was clear. Eye rubbing could be a possible adjuvant risk factor that contributes to conversion of FFK to clinical progressive keratoconus.
Highlights
Keratoconus appears as an independent and isolated disorder, there are many keratoconic cases related with atopy, connective tissue disorders, referred eye rubbing and contact lens intolerance [1]
Eye rubbing is deemed a significant predictor for keratoconus progression and it is considered abnormal in connection with frequency, intensity and duration [3]
In this case we present a keratoconic patient’s family in which all members are affected by Forme Fruste Keratoconus (FFK) documented by Dual-Scheimpflug topography
Summary
Keratoconus appears as an independent and isolated disorder, there are many keratoconic cases related with atopy, connective tissue disorders, referred eye rubbing and contact lens intolerance [1]. (2015) Eye Rubbing as a Possible Cause of Clinical Progressive Keratoconus in a Forme Fruste Keratoconic Family. In these cases familial keratoconus inheritance follows the autosomal dominant and/or recessive pattern [2]. It is supported that rubbing-related mechanical epithelial trauma is responsible for the release of inflammatory mediators, which contribute to keratoconus pathogenesis [3]. In this case we present a keratoconic patient’s family in which all members (including the two parents and their four children) are affected by Forme Fruste Keratoconus (FFK) documented by Dual-Scheimpflug topography. Clinical progressive keratoconus was evident in the only family member that reported eye rubbing
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