Eye Diseases Monitoring Using Statistical Analysis of Disc Topography and RNFL Circular Tomogram Parameters

Abstract

In this paper, Statistics method for data taken from ophthalmology institute of Cairo, Egypt used to pinpoint the absolute measurement precision of high resolution technique of Topcon three dimensional optical coherence topography FA plus (Topcon 3D OCT FA plus) parameters by expressing them as limit of agreement percentage ( LA95%) then, suggest a method for mathematically evaluating the ability of parameter to monitor ailment progression expressed as Discriminate Capacity Index (DCI) then, select parameters suitable for both conversion to glaucoma and modify to outright glaucoma . The used Parameters were area of disc, cup, rim and cup to disc ratio, linear and veridical cup to disc ratio, volume of cup, rim volume, horizontal and vertical diameter, total thickness of retinal nerve fiber layer (RNFL), average superior thickness of RNFL and average inferior thickness of RNFL parameters have been arranged with a DCI ≥ 0.4 for glaucoma detection and with a DCI≥ 2.3 for continue of glaucoma. The most adequate parameters for both detection and follow-up of glaucoma are Inferior thickness of RNFL (DCI=4.1976), total thickness of RNFL (DCI=16.56) and vertical cup- to- disc ratio (CDR) (DCI=22.1875).